1.a serious (sometimes fatal) infection of rodents caused by Yersinia pestis and accidentally transmitted to humans by the bite of an infected rat flea (especially bubonic plague)
2.any epidemic disease with a high death rate
3.a swarm of insects that attack plants;
a plague of grasshoppers
4.any large scale calamity (especially when thought to be sent by God)
5.an annoyance;
those children are a damn plague
1.cause to suffer a blight;
Too much rain may blight the garden with mold
2.annoy continually or chronically;
He is known to harry his staff when he is overworked